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How to untie it-translocation of a knotted protein through a pore

Szymczak, P (University of Warsaw, Poland)
Tuesday 04 September 2012, 11:50-12:10

Seminar Room 1, Newton Institute


Proteins need to be unfolded when translocated through the pores in mitochondrial and other cellular membranes. Knotted proteins, however, might get stuck during this process since the diameter of the pore is smaller than the size of maximally tightened knot. We report the result of computer simulations of knotted protein translocation, which show how the protein can avoid the topological traps and untie its knot during the translocation

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