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The role of topological constraints on condensed polymers and DNA in human cells

Mirny, L (Massachusetts Institute of Technology, USA)
Monday 03 September 2012, 11:30-12:10

Seminar Room 1, Newton Institute


Human DNA is two meters long and is folded into a structure that fits in a cell nucleus of just 5 microns in diameter. Recently developed Hi-C technique provides comprehensive information about genome folding. Our analysis of Hi-C data provides and biophysical polymer modeling show that scaling observed in the data is consistent with non-equilibrium and unknotted polymer state the crumpled (fractal) globule. We demonstrate that the fractal globule emerges as a result of polymer collapse and has a short lifetime, rapidly mixing while remaining largely unknotted. Long-time dynamics of a condensed polymer reveals that spatial and topological equilibration happen at vastly different time scales and that topological constrains have little effect on relatively short and flexible chains.


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