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A stochastic model of coupled enzymatic degradation

Williams, R (UC, San Diego)
Wednesday 24 March 2010, 09:30-10:30

Seminar Room 1, Newton Institute


Joint work with Natalie Cookson, Jeff Hasty, Will Mather, Octavio Mondragon-Palomino and Lev Tsimring A major challenge for systems biology is to deduce the molecular interactions that underly correlations observed between concentrations of different intracellular molecules. While direct explanations such as coupled transcription/translation or direct protein-protein interactions are often considered, potential indirect sources of coupling have received much less attention. In this talk, I will report on an investigation involving both theory and experiment of how correlations can arise generically from a post-translational coupling mechanism involving the processing of multiple protein species by a common enzyme.

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