Within-host Dynamics of Viral Infections
Seminar Room 1, Newton Institute
Viruses make many cycles of many generations of selection within one host and a single generation of selection at the population level. At the within-host level, a virus evolves mutations to escape from the unique immune responses mounted by an individual host. Because of the massive heterogeneity of MHC molecules in natural populations, these adaptive mutations are expected to be detrimental in future hosts. The within-host viral fitness determines virulence and infectiousness, and hence the basic reproduction number (R0) at the population level. The aim of our research is to investigate the implications of the above described intertwined selection mechanisms.