The INI has a new website!

This is a legacy webpage. Please visit the new site to ensure you are seeing up to date information.

Skip to content

DAE

Seminar

A cluster-randomised cross-over trial

White, I (MRC)
Monday 15 August 2011, 16:35-17:15

Seminar Room 1, Newton Institute

Abstract

I will describe a trial which combined a cluster-randomised design with a cross-over design. The Preterm Infant Parenting (PIP) trial evaluated a nurse-led training intervention delivered to parents of prematurely born babies to help them meet their babies' needs. An individually randomised trial risked extensive "contamination" of parents in the control arm with knowledge of the intervention, so the investigators instead randomised neonatal units. However, neonatal units differ widely, and only 6 neonatal units were available, so a conventional cluster randomised design would have been underpowered. In the selected design, the six neonatal units were randomly allocated to deliver intervention or control to families recruited during a first 6-month period; after a 2-month interval, each unit then delivered the opposite condition to families recruited during a second 6-month period.

I will present the relative precisions of individually randomised, cluster-randomised and cluster-crossover designs, and design issues including the need for a wash-out period to minimise carry-over. The analysis can be conveniently done using cluster-level summaries. I will end by discussing whether cluster-crossover designs should be more widely used.

Presentation

[pdf ]

Video

The video for this talk should appear here if JavaScript is enabled.
If it doesn't, something may have gone wrong with our embedded player.
We'll get it fixed as soon as possible.

Back to top ∧