Approximation of the individual Fisher information matrix and its use in design of population PK/PD studies
Seminar Room 1, Newton Institute
AbstractWe continue a discussion started at PODE 2010 meeting about different types of approximation of the individual Fisher information matrix and their use in design of population PK/PD studies which are described by nonlinear mixed effects models. We focus on several Monte Carlo-based options and provide examples of their performance.
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