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Restitution curve splitting as a mechanism for the bifurcation to alternans

Cherry, E (Cornell)
Monday 20 July 2009, 15:45-16:00

Seminar Room 1, Newton Institute


Cardiac tissue displays a bifurcation in electrical response at rapid pacing rates. Traditionally, this bifurcation has been explained in terms of the slope of the restitution curve, a function that relates the response duration to the duration of the interval preceding it. However, we have recently observed that this curve is not a single-valued function under a wide range of physiological conditions. We will show examples of this restitution curve splitting and discuss the implications.


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